Scientist/Sr Scientist – R&D Manufacturing

About this role

Sr Scientist – Early Process Development & Manufacturing (lentiviral vectors) permanent Location: Belgium , Mont-Saint-Guibert Salary: Competitive Introduction to role Are you ready to dive into the world of transformative therapies and make a significant impact? At EsoBiotec, now part of AstraZeneca, we are setting new benchmarks for biotechnological research. Our collaboration combines AstraZeneca’s global influence and scientific innovation with EsoBiotec’s unique culture of creativity and breakthroughs in cell-based therapies and immunology. Here, your scientific passion will drive real-world impact as you contribute to life-changing treatments

We are looking for an inspiring discovery scientist to drive innovation and development of our pioneering lentiviral vector therapeutic platform. Join us in shaping the future of cell and gene therapy with your expertise in viral vector engineering, gene editing, CAR and TCR T cell engineering or myeloid immunobiology in cancer. Responsibilities Plan and execute the downstream purification of R&D grade vectors using scaled down/adapted clinical manufacturing processes to support R&D groups with high quality supply of vectors

Test manufacturability of novel in vivo lentiviral vectors engineered in vector discovery and/or built in the vector development group. Develop and optimize downstream manufacturing processes for in vivo lentiviral vectors in collaboration with global process development team. Execute hypothesis-driven process development experiments that translate discovery insights into robust, product-relevant unit operations

Support cell line and producer cell development, selection, and characterization to enable consistent LVV production and process robustness. Prepare technical documentation including development reports and process descriptions that enable internal reviews and external transfers. Collaborate closely with discovery, vector engineering, and CMC stakeholders to ensure manufacturability consid

Apply for this role on AstraZeneca’s official careers site.